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    4 reasons human tissues should be used to help predict bioavailability of drugs

    Oral administration continues to be the most common route of drug delivery. As pharmacological development costs continue to rise, ADME/DMPK researchers are keen to pursue models which can more effectively predict human bioavailability.  In this post we will explore why accurate prediction of gastrointestinal (GI) permeability is important, and list four key benefits to using fresh human tissue to estimate drug permeability. 

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    How to estimate drug permeability using an Ussing Chamber

    Ussing chambers represent a flexible and cost-effective means of investigating mucosal drug transport or drug-mediated effects on tissue behavior, including ion transport, drug metabolism and absorption. In this post, we will describe how the Ussing system can be used to accurately predict the bioavailability of test articles before clinical trial.

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    On the right path to a cure for IBD

    Advances in diagnostics, treatments, and frontiers of research

    In light of World Digestive Disease Day, which is celebrated every year on the 29th of May[1], we will explore the different facets of Inflammatory bowel disease (IBD) and highlight recent advances on the diagnostics, treatments, and the frontiers of research that will one day hopefully provide a cure.

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    New publication by Roche on diarrheal toxicity induced by anti-HER2/3 combination therapy includes REPROCELL human fresh tissue data

    A publication in Molecular Cancer Therapeutics has shed new light on the mechanisms by which anti-HER2/3 combination therapies can cause diarrhea.

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