Tissue Sourcing for the Development of iPSC-derived Disease Models

Human induced pluripotent stem cells (iPSCs)-based models are an ideal resource for studying disease mechanisms in vitro at the cellular level[1], screening potential new therapeutics[2], and investigating the propensity and mechanism for the development of toxic side effects caused by drug treatment[3]. Such iPSC-based models enable studies to be performed under defined experimental conditions and in a reproducible manner.

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TISSUE SPOTLIGHT: Skin

In this issue, we are casting the REPROCELL Tissue Spotlight on the SKIN.

In humans, the largest organ in the body is the skin layer, accounting for up to 15% of the total body weight and a surface area of up to 2m2. It is composed of several layers — the epidermis, dermis and the sub-cutaneous layer, the hypodermis — each crucial to the many functions of the skin ranging from a protective barrier for internal tissues and organs, through regulation of body temperature and nutrient absorption, to the generation of vitamin D.

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TISSUE SPOTLIGHT: Intestines

In this issue, we are casting the REPROCELL Tissue Spotlight on the INTESTINES.

The intestines (large and small) are vital organs in the gastrointestinal tract of our digestive system. Comprising a winding muscular tube extending from the stomach to the anus the main purpose is to digest food and absorb nutrients. The intestines also have a key role to play in the processes of cellular messaging, fighting infection and in regulating the body’s water balance.

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The Human Touch: meeting clinical needs in IBD research

There is a clinical need for novel therapies in Inflammatory Bowel Disease. Current research is however limited by models which do not physiologically mimic the disease in humans. REPROCELL’s Human IBD Fresh Tissue Assay is the most clinically relevant IBD model on the market and the only commercially available assay of its kind.

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New publication by Roche on diarrheal toxicity induced by anti-HER2/3 combination therapy includes REPROCELL human fresh tissue data

A publication in Molecular Cancer Therapeutics has shed new light on the mechanisms by which anti-HER2/3 combination therapies can cause diarrhea.

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Human Tissue Experts REPROCELL Launch New Customized Primary Cell Isolation Services

REPROCELL’s BioServe and Biopta tissue procurement networks combine to create a new service isolating human primary cells.

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REPROCELL’s footprint extends to serve life sciences in India

REPROCELL India (formerly BioServe Biotechnologies) is a state-of-the-art biotechnology company with a mission to serve the life sciences research ecosystem.

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The Benefits of Human Tissue to Drug Discovery and Development

Progressive and innovative Pharmaceutical and Biotechnology companies ask themselves several key questions when it comes to Drug Discovery and Development:

• How and where can we be research smarter? 
• How can we reduce uncertainty? 
• How can we better predict efficacy and safety? 
• How can we reduce costs?

One route to making the drug discovery process smarter and more efficient is to use human tissue at one or more stages in the development process.

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Xeno-free culture of pluripotent stem cells in NutriStem® hPSC XF medium

Pluripotent stem cells (PSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are a key component of the growing field of regenerative medicine. Use of culture conditions free of animal products (xeno-free) is essential for PSC projects that are destined for the clinic. NutriStem hPSC XF medium (01-0005) and iMatrix-511 recombinant human laminin-511 E8 fragments (NP892-011) form an ideal system for xeno-free, feeder culture of human PSCs.

 

Check out our NutriStem Midwinter Sale

15% - 35% and more off 500 mL bottles.

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Offer expires 15 March 2018. Offer not valid in Asia.

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Formation of human tissue to improve drug testing and reduce animal research

REPROCELL’s Alvetex, a scaffold for 3D cell culture and bioengineered tissue models, is in the Durham University (UK) News yesterday, at https://www.dur.ac.uk/news/newsitem/?itemno=33385

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