4 reasons human tissues should be used to help predict bioavailability of drugs

    Oral administration continues to be the most common route of drug delivery. As pharmacological development costs continue to rise, ADME/DMPK researchers are keen to pursue models which can more effectively predict human bioavailability.  In this post we will explore why accurate prediction of gastrointestinal (GI) permeability is important, and list four key benefits to using fresh human tissue to estimate drug permeability. 

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    How to estimate drug permeability using an Ussing Chamber

    Ussing chambers represent a flexible and cost-effective means of investigating mucosal drug transport or drug-mediated effects on tissue behavior, including ion transport, drug metabolism and absorption. In this post, we will describe how the Ussing system can be used to accurately predict the bioavailability of test articles before clinical trial.

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    How SynFire® Technology can benefit your research

    In celebration of our distributorship with NeuCyte, REPROCELL catches up with NeuCyte’s Head of Neuroscience, Dr Daniel Haag, to discuss the benefits of SynFire technology. Read on to find out the science behind this technology, and how using human neural models can benefit your drug discovery and toxicology research.

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    How to determine CRISPR gene editing success in 2 weeks

    Imagine CRISPR – but more efficient, reliable and flexible. SNIPER works in synergy with the CRISPR-Cas9 system to fulfill even the most challenging gene editing projects – including biallelic modifications, single base-pair changes and large DNA insertions. Read on to discover four examples of CRISPR-SNIPER in action.

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