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    Author: Zara Puckrin

    Marketing Manager at REPROCELL
    Zara is a GCU graduate based at our Glasgow office. She loves minimalism, marketing and molecular biology. You can contact her on LinkedIn.

    3 challenges facing the introduction of iPSC-derived therapies

    There are many benefits to the introduction of iPSC-derived therapies including improved patient quality of life, decreased clinical drug attrition rates, and reduced pressure on healthcare systems. However, there is still much work to be done before these therapies can become clinically available [1,2]. In this post, we will explore three challenges currently facing the widespread introduction of iPSC therapies to regenerative medicine.

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    4 ways stem cells be used in medical treatments

    Stem cell therapeutics promise to solve many medical and scientific problems. However, the introduction of these therapies is limited by our lack of knowledge about their effects in humans. In this post, we will review four future applications of clinical-grade induced pluripotent stem cells (iPSCs) in medicine and research – including their use in drug discovery and regenerative therapeutics.

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    4 reasons human tissues should be used to help predict bioavailability of drugs

    Oral administration continues to be the most common route of drug delivery. As pharmacological development costs continue to rise, ADME/DMPK researchers are keen to pursue models which can more effectively predict human bioavailability.  In this post we will explore why accurate prediction of gastrointestinal (GI) permeability is important, and list four key benefits to using fresh human tissue to estimate drug permeability. 

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    How to estimate drug permeability using an Ussing Chamber

    Ussing chambers represent a flexible and cost-effective means of investigating mucosal drug transport or drug-mediated effects on tissue behavior, including ion transport, drug metabolism and absorption. In this post, we will describe how the Ussing system can be used to accurately predict the bioavailability of test articles before clinical trial.

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    4 TED Talks discussing the future of regenerative medicine

    Regenerative medicine promises a healthier workforce and increased quality of life. However, the introduction of regenerative therapies will require careful regulatory and technical considerations from both researchers and clinicians. In this blog post, we describe four informative TED Talks that explore the future of regenerative medicine and the limitations preventing its introduction.

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    How to Characterize Stem Cells using Immunocytochemistry

    Planning an immunocytochemistry (ICC) project can be tricky as it requires careful selection of compatible antibodies, fluorochromes, and blocking reagents. In this article our scientists have provided a step-by-step guide for single staining of iPSCs, plus trouble-shooting tips to optimize your results. 

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    What are the advantages of an internship to employers?

    The current job market is a confusing, intimidating place for both employers and applicants. Internships are an excellent opportunity to access future talent at an early stage, and also present a range of additional benefits. In this post, we will describe 4 ways that hiring an intern can benefit your team and business.

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    5 ways SNIPER can enhance your CRISPR gene editing

    Most biologists are familiar with the precision gene editing system CRISPR. But what about SNIPER? SNIPER is a digital PCR (dPCR) and culture-based screening technology that has the power to enhance CRISPR-Cas9 gene editing, enabling multiplex gene modification, biallelic gene insertions and increased screening efficiency. Read on to find out more about how SNIPER can enhance your precision gene editing protocols and save you time, money and effort.

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    How to determine CRISPR gene editing success in 2 weeks

    Imagine CRISPR – but more efficient, reliable and flexible. SNIPER works in synergy with the CRISPR-Cas9 system to fulfill even the most challenging gene editing projects – including biallelic modifications, single base-pair changes and large DNA insertions. Read on to discover four examples of CRISPR-SNIPER in action.

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    Improving patient outcomes through collaboration

    The return on R&D investments in the UK is at its lowest rate in nine years, despite Britain’s global presence in science, technology and health. Pharmaceutical attrition rates continue to rise, and the UK biotech landscape remains fragmented. Medicines Discovery Catapult (MDC) aims to connect the UK R&D community more effectively by putting the patient at the heart of the drug discovery process. As part of our collaboration with the MDC, REPROCELL have pledged to provide custom drug discovery assays using live human tissues.

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