Author: Karen McAulay

    Karen McAulay, Ph.D.
    Clinical Alliance Manager, REPROCELL

    Improve your gene-editing success with CRISPR-SNIPER technology

    The discovery of both CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated proteins, the Cas nucleases, has revolutionized the field of gene-editing.  Characterization of the role of the CRISPR-Cas system in pathogen detection, the immune response, and DNA repair mechanisms, has enabled this naturally occurring biological system to be harnessed and developed as a valuable research tool.

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    This issue, we are casting the REPROCELL Tissue Spotlight on the LUNG.

    The lungs are the central organs of the human respiratory system enabling you to take around 25,000 breaths a day — mostly, without any conscious thought that you are doing so!

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    In this issue, we are casting the REPROCELL Tissue Spotlight on the SKIN.

    In humans, the largest organ in the body is the skin layer, accounting for up to 15% of the total body weight and a surface area of up to 2m2. It is composed of several layers — the epidermis, dermis and the sub-cutaneous layer, the hypodermis — each crucial to the many functions of the skin ranging from a protective barrier for internal tissues and organs, through regulation of body temperature and nutrient absorption, to the generation of vitamin D.

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    TISSUE SPOTLIGHT: Intestines

    In this issue, we are casting the REPROCELL Tissue Spotlight on the INTESTINES.

    The intestines (large and small) are vital organs in the gastrointestinal tract of our digestive system. Comprising a winding muscular tube extending from the stomach to the anus the main purpose is to digest food and absorb nutrients. The intestines also have a key role to play in the processes of cellular messaging, fighting infection and in regulating the body’s water balance.

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    The Benefits of Human Tissue to Drug Discovery and Development

    Progressive and innovative Pharmaceutical and Biotechnology companies ask themselves several key questions when it comes to Drug Discovery and Development:

    • How and where can we be research smarter? 
    • How can we reduce uncertainty? 
    • How can we better predict efficacy and safety? 
    • How can we reduce costs?

    One route to making the drug discovery process smarter and more efficient is to use human tissue at one or more stages in the development process.

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